The popular comedy act came in first place as the series drew to a close.
Lee, 37, won the title after a tense showdown with Robert White and Donchez Dacres.
He suffers from neurological condition cerebral palsy which means he is unable to speak, so he uses a voice synthesizer to complete his routines.
The Geordie looked incredibly nervous as he waited for the results to be read out by host Declan Donnelly, and he went wild when his named was called out.
He was seen hugging Dec and bouncing up and down in sheer joy as he celebrated his win.
Speaking via his via his synthesizer, Lee said: “I have been blown away by the support of the judges and general public.
“I’ve had so much love for everyone and I’m grateful for it all.”
Lee even managed to make a joke when Dec told him he will doing his set for the Queen at the Royal Variety Performance.
He quipped that he loves the Queen, especially her song Bohemian Rhapsody.
His big win comes after a sensational final, which Dec started with a spectacular song and dance number as he shimmied with a group of scantily-clad Brazilian dancers, did some high kicks and even completed a handstand.
Viewers flocked to Twitter to praise his performing skills, with many suggested Dec should be crowned winner himself for his sensational show.
One wrote: “Dec should win BGT with that opening 😆 Outstanding @antanddec #BGT.”
Another tweeted: “Dec ( @antanddec ) is really stealing the show tonight #bgt.” (Courtesy The SUN)