Wiese has joined the exodus of South African international cricketers who have opted for the security of an English county contract, signing a three-year deal with Sussex.
Cricket South Africa (CSA) said that selectors initially included Wiese, 31, in the squad, but his switch effectively ends his international career for South Africa.
Five players uncapped at international level are in the squad, as well as all-rounder Andile Phehlukwayo, who has only played in one-day internationals previously.
Star batsman AB de Villiers, who has not played since June last year because of an elbow injury, and fast bowler Morne Morkel, recovering from a back injury, are due to play in a domestic one-day game on January 22 and may be considered for the third and final T20 international, in Cape Town on January 25.
South African squad:
Farhaan Behardien (captain), Theunis de Bruyn, Reeza Hendricks, Imran Tahir, Heino Kuhn, David Miller, Mangaliso Mosehle (wkt), Lungi Ngidi, Wayne Parnell, Dane Paterson, Aaron Phangiso, Andile Phehlukwayo, Jon-Jon Smuts. (Courtesy News 18)